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The main research interests of the Institute are voltage-dependent ion channels, primarily sodium and potassium channels. In the last few years we have concentrated on two topics, the role of S4 transmembrane segments in voltage sensing, and the interaction between permeation and gating. This is not a comprehensive list of work. If you would like to submit a reprint request for any of our works, please email Mary Ryan.
21st Century Publications
Mary Y. Ryan, Rachel Maloney, Robert Reenan and Richard Horn. Characterization of five RNA editing sites in Shab potassium channels. Channels. 2008 May/June; 2(3): pages coming soon. Link
Christopher A. Ahern, Amy L. Eastwood, Dennis A. Dougherty and Richard Horn. Electrostatic contributions of aromatic residues in the local anesthetic receptor of voltage-gated sodium channels. Circ Res. 2008 Jan 4; 102(1):86-94. Link
Vincent P. Santarelli, Amy L. Eastwood, Dennis A. Dougherty, Christopher A. Ahern and Richard Horn. "Calcium block of single sodium channels: role of a pore-lining aromatic residue." Biophys J. 2007 Oct; 93(7):2341-9. Link
Vincent P. Santarelli, Amy L. Eastwood, Dennis A. Dougherty, Richard Horn and Christopher A. Ahern. "A cation-pi interaction discriminates among sodium channels that are either sensitive or resistant to tetrodotoxin block." J Biol Chem. 2007 March;(282)11:8044-51. Link
Christopher A. Ahern, Amy L. Eastwood, Henry A. Lester, Dennis A. Dougherty and Richard Horn. "A cation-pi interaction between extracellular TEA and an aromatic residue in potassium channels." J Gen Physiol. 2006 Dec;128(6):649-57.Link
Richard Horn. "Electrifying Phosphatases." Sci STKE (2005) 307: 50-52. Link
Christopher A. Ahern and Richard Horn.
"Focused Electric Field across the
Voltage Sensor of Potassium Channels." Neuron (2005) 48: 25-29.
Link
Shinghua Ding, Lindsey Ingleby, Christopher A. Ahern, and Richard Horn. "Investigating the Putative Glycine Hinge in Shaker Potassium Channel." J. Gen. Physiol. (2005) 123: 213-226. Link
Christopher A. Ahern, Ji-Fang Zhang, Marilyn J. Woolkalis, and Richard Horn. "Modulation of the Cardiac Sodium Channel NaV1.5 by Fyn, a Src Family Tyrosine Kinase." Circulation Research (2005) Vol. 96 (9): 991-998. Link
Richard Horn. "How ion channels sense membrane potential." PNAS (2005) Vol. 102, No. 14: 4929-4930. Link
Christopher A. Ahern and Richard Horn. "Stirring up controversy with a
voltage sensor paddle." Trends in Neuroscience. (2004) 27: 303-307.
Link
Christopher Ahern and Richard Horn. "Specificity of Charge-carrying
Residues in the Voltage Sensor of Potassium Channels." J. Gen. Physiol.
(2004) 123: 205-216.
Link
Richard Horn. "Commentary. How S4 Segments Move Charge. Let Me
Count the Ways." J. Gen. Physiol. (2004) 123: 1-4.
Link
Shinghua Ding and Richard Horn. "Effect of S6 Tail Mutations on Charge
Movement in Shaker Potassium Channels." Biophysical Journal (2003) 84:
295-305.
Link
Richard Horn. "Coupled Movements in Voltage-Gated Ion Channels." J.
Gen. Physiol. (2002) 120: 449-453.
Link
Thao Nguyen and Richard Horn. "Movement and Crevices Around a Sodium
Channel S3 Segment." J. Gen. Physiol. (2002) 120: 419-436.
Link
Shinghua Ding and Richard Horn. "Tail End of the S6 Segment: Role in
Permeation in Shaker Potassium Channels." J. Gen. Physiol. (2002) 120:
87-97.
Link
Shinghua Ding and Richard Horn. "Slow Photo-Cross-Linking Kinetics of
Benzophenone-Labeled Voltage Sensors of Ion Channels." Biochemistry
(2001) 40:10707-10716.
Richard Horn. "Conversation between voltage sensors and gates of ion
channels." Biochemistry (2000) 39:15653-15658.
Richard Horn, Shinghua Ding, and Hermann J.
Gruber.
"Immobilizing the Moving Parts of Voltage-gated Ion Channels." Journal
of General Physiology (2000) 116:461-476.
Link
Richard Horn. "A New Twist in the Saga of
Charge Movement in Voltage-Dependent Ion Channels." Neuron (2000) 25:
511-514.
Nenad Mitrovic, Alfred L. George, Jr.,
and Richard Horn. "Role of Domain 4 in Sodium Channel Slow
Inactivation." Journal of General Physiology (2000) 115:707-718.
Link
S4 Segments: The
Voltage Sensor
Mitrovic, N., George, A. L., and Horn, R. "Independent versus coupled
inactivation. Role of the domain 2 S4 segment in sodium channels."
Journal of General Physiology (1998) 111:451-462.
Link
Yang, N., George, A. L., and Horn, R. "Probing the outer vestibule of a sodium channel voltage sensor." Biophysical Journal (1997) 73:2260-2268.
Yang, N., George, A. L., and Horn, R. "Molecular basis of charge movement in voltage-gated sodium channels." Neuron (1996) 16:113-122.
Ji, S., George, A.
L., Horn, R., and Barchi, R. L. "Paramyotonia congenita mutations reveal
different roles for segments S3 and S4 of domain D4 in hSkM1 sodium
channel gating." Journal of General Physiology (1996) 107:183-194.
Link
French, R. J., Prusak-Sochaczewski, E., Zamponi, G. W., Becker, S.,
Kularatna, A. S., and Horn, R. "Interactions between a pore-blocking
peptide and the voltage sensor of the sodium channel: an electrostatic
approach to channel geometry." Neuron (1996) 16:407-413.
Chen, L.-Q., Santarelli, V., Horn, R., and Kallen, R. G. "A unique role
for the S4 segment of domain 4 in the inactivation of sodium channels."
Journal of General Physiology (1996) 108:549-556.
Link
Yang, N. and Horn, R. "Evidence for voltage dependent S4 movement in sodium channels." Neuron (1995) 15:213-218.
Conversation Between the Gates and the Permeation Pathway
Townsend, A. and Horn, R. "Interaction between the pore and a fast
gate of the cardiac sodium channel." Journal of General Physiology
(1999) 113:321-331.
Link
Townsend, C., Hartmann, H. A., and Horn,
R. "Anomalous effect of permeant ion concentration on peak open
probability of cardiac Na+ channels." Journal of General Physiology
(1997) 110:11-21.
Link
Townsend, C. and Horn, R. "Effect of
alkali metal cations on slow inactivation in cardiac Na+ channels."
Journal of General Physiology (1997) 110:23-33.
Link
